Eric M. Verdin, MD

Associate Director and Senior Investigator

Phone: (415) 734-4808
Fax: (415) 355-0855
Fewer scientific details, please
Download a Printable PDF

Other Professional Titles

Investigator, Roddenberry Center for Stem Cell Biology and Medicine at Gladstone

Professor, Medicine, University of California, San Francisco

Administrative Assistant

Veronica Fonseca
(415) 734-4809
vfonseca@gladstone.ucsf.edu

More about Dr. Verdin

Dr. Verdin studies the molecular virology of HIV and novel approaches to eradicate HIV infection. Dr. Verdin’s laboratory also studies basic mechanisms of aging and focuses on a family of proteins—called histone deacetylases—and their role in the aging process. He joined the Gladstone Institute of Virology and Immunology in 1997 and became the associate director in 2004.

Dr. Verdin was elected as a fellow of the American Association for the Advancement of Science and as a member of the American Society for Clinical Investigation and the Association of American Physicians. Dr. Verdin also serves on the National Scientific Advisory Council of the American Federation for Aging Research. For his aging research, Dr. Verdin was recognized with a Glenn Award for Research in Biological Mechanisms of Aging and a senior scholarship from the Ellison Medical Foundation. His work on HIV was recognized by an Avant-Garde Award from the National Institutes of Health (NIH).

Dr. Verdin has served as reviewer on study sections for the NIH, as the organizer of international meetings and as the editor of several books and reviews. He has published more than 150 international papers and is associated with 10 patents.

Originally from Belgium, Dr. Verdin earned his MD from the University of Liege,
in Belgium. He trained at Harvard Medical School and has held faculty positions at the University of Brussels, Belgium, the NIH, Maryland, and the Picower Institute for Medical Research, New York.

More scientific details, please

Other Professional Titles

Investigator, Roddenberry Center for Stem Cell Biology and Medicine at Gladstone

Professor, Medicine, University of California, San Francisco

Administrative Assistant

Veronica Fonseca
(415) 734-4809
vfonseca@gladstone.ucsf.edu

Areas of Investigation

Our laboratory explores different aspects of the biology of reversible protein acetylation, a postranslational modification that is gaining increasing recognition as an important biological regulatory mechanism. We’re specifically interested in the enzymes that remove acetyl groups from protein called the histone/protein deacetylases (HDACs).

Current Lab Focus

What is the role of protein acetylation across the three following biological systems:

  1. Transcriptional regulation of HIV expression
  2. Mechanism of positive and negative selection during thymocyte development
  3. Role of mitochondrial protein deacetylases

Joined Gladstone

1997

Why Gladstone?

Gladstone offers a unique research environment at the interface between basic science and translational research

Key Achievements

  • Solved the chromatin organization of the HIV promoter and identified a chromatin remodeling event occurring during transcriptional activation.
  • First to report that the latent HIV promoter is reactivated by histone deacetylase inhibitors.
  • Identified the first commercially available histone deacetylase inhibitor (SAHA-Vorinostat) in collaboration with Paul Marks group.
  • Cloned and characterized HDAC3, HDAC4, HDAC5, HDAC6 and HDAC7.
  • Identified the HIV Tat protein as an acetylated protein.
  • Cloned and identified the mammalian sirtuins (SIRT1 through 7).
  • Identified SIRT3 as a mitochondrial protein deacetylase and characterized its first target, acetylCoA synthetase.
  • Identified HDAC7 as a regulator of thymic positive and negative selection.
  • Reported that SIRT5 is a demalonylase, desuccinylase enzyme (collaboration with Yingming Zhou).

Education

University of Liege, Belgium (MD), Honors (1982)
Harvard Medical School, Joslin Diabetes Center, Postdoctoral training

Affiliations

American Society for Microbiology
Molecular Medicine Society (Charter Member)
American Society for Biochemistry and Molecular Biology
Fellow, American Association for the Advancement of Science
American Federation for Aging Research (AFAR) National Scientific Advisory Council

Editorial Board, Chemtracts
Editorial Board, PLoS One
Editorial Board, Molecular Cellular Biology
Editorial Board, Virology
Editorial Board, Aging
Editorial Board, Clinical Epigenetics

Awards

  • Recipient of the Avant-Garde Award from the National Institute of Drug Abuse (NIDA) (2010)
  • Co-organizer, Epigenetics Symposium (2008)
  • Senior Scholar in Aging, Ellison Medical Foundation (2003)
  • Chair, Novartis Symposium on Protein Acetylation, London (2003)
  • Elected to American Society for Clinical Investigation (1999)
  • Elected to Association of American Physicians (1997)
Syndicate publications

Featured Publications

Eric M. Verdin, MDRafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency. PLoS Biol. 2011 Nov; 9(11):e1001206. View in: PubMed
Eric M. Verdin, MDHirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. View in: PubMed