Marielle Cavrois, PhD

Staff Research Scientist

Phone: (415) 734-4824
Fax: (415) 355-0153
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Other Professional Titles

Director, Flow Cytometry Core and BSL3 Laboratory
Adjunct Assistant Professor, Department of Medicine, University of California, San Francisco

Administrative Assistant

Sue Cammack: (415) 734-4806
scammack@gladstone.ucsf.edu

More about Dr. Cavrois

In her role as Core director, Dr. Cavrois oversees the use and maintenance of state-of-the-art instruments that analyze and separate cells according to detailed specifications, such as cell type or the expression of certain genes within the cell. The images and data produced by the Flow Cytometry Core facilitate the research of investigators throughout Gladstone—and at other institutions. Dr. Cavrois also provides training on the techniques and features of flow cytometry to students, postdoctoral fellows and faculty.  

In addition to directing the Flow Cytometry Core, Dr. Cavrois conducts her own research, which focuses on understanding the initial biological processes that occur during HIV infection—key factors in the development of effective vaccines and compounds (microbicides) that can help reduce or prevent infection.

Dr. Cavrois has received numerous awards for her work, including fellowship awards from the Foundation for Medical Research, the Cancer Research Institute, the French Minister of Research and Technology and the University of California, San Francisco, AIDS Research Program.

Dr. Cavrois is a member of the International Society for the Advancement of Cytometry. Since 2009 she has served as an ad hoc reviewer for the Journal of Virology.

A native of France, Dr. Cavrois earned a bachelor’s degree in biology and a master’s degree in biochemistry from the University of Caen, France.  She earned a PhD (summa cum laude) from the University of Lille, France. She was a postdoctoral fellow at the Institute of Human Virology, at the University of Maryland School of Medicine, before completing her postdoctoral training at GIVI.

More scientific details, please

Other Professional Titles

Director, Flow Cytometry Core and BSL3 Laboratory
Assistant Adjunct Professor, Department of Medicine, University of California, San Francisco

Administrative Assistant

Sue Cammack: (415) 734-4806
scammack@gladstone.ucsf.edu

Areas of Investigation

Mucosal transmission of HIV is a major force driving expansion of the global AIDS epidemic and women bear the greatest burden of new HIV infections throughout the world. Our research focusing on understanding the initial events in the establishment of infection in a new host is key to developing an effective vaccine and microbicides.

Current Lab Focus

We are currently developing a second-generation fusion assay to measure fusion of HIV virus circulating in the population and characterize the fusion phenotype of viruses transmitted to new hosts.

Joined Gladstone

2000

Why Gladstone?

I joined Gladstone for my post-doctoral studies. At that time, Gladstone already had a very strong reputation for being an excellent place for post-doctoral trainees and its reputation is still growing.

Key Achievements

  • Developed the HIV- fusion assay to measure entry of HIV in its target cell.
  • Demonstrated that Dendritic cells transfer surface bound-HIV to T cells and not internalized virions.
  • Showed that HIV fusion to dendritic cells decreases as cells mature.
  • Showed that clonal expansion of HTLV-1 infected cells plays a key role in HTLV pathogenesis.

Education

University of Caen, France (BSc), Biology (1989)
University of Caen, France (MSc), Biochemistry (1992)
University of Lille, France (PhD), Summa Cum Laude), Molecular and Cellular Biology (1997)

Affiliations

International Society for Advancement of Cytometry

Awards

  • Travel Award CROI (2003)
  • University-wide AIDS Research Program Fellowship Award (2003)
  • Travel Award CROI (2001)
  • Foundation for Medical Research, Fellowship Award (1998)
  • Cancer Research Institute Fellowship Award (1997)
  • French Minister of Research and Technology Fellowship Award (1993)
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