Publications

Steve Finkbeiner, MD, PhDBilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5803-8. View in: PubMed
Li Gan, PhDPoly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid ß. View in: PubMed
Li Gan, PhDKauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid ß. J Neuroinflammation. 2011; 8:152. View in: PubMed
Yadong Huang, MD, PhDBien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aß accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 4; 32(14):4803-11. View in: PubMed
Yadong Huang, MD, PhDArf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One View in:
Anatol Kreitzer, PhDKravitz AV, Tye LD, Kreitzer AC. Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nat Neurosci. 2012 Apr 29. View in: PubMed
Robert Mahley, MD, PhDSmall-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein e4-associated neuropathology. View in: PubMed
Robert W. Mahley, MD, PhDChen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Small molecule structure correctors abolish detrimental effects of apolipoprotein e4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66. View in: PubMed
Lennart Mucke, MDLevetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. View in: PubMed
Lennart Mucke, MDVerret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012 Apr 27; 149(3):708-21. View in: PubMed