Gladstone in the News
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The difference between HIV infection and full-blown AIDS is, in large part, the massive die-off of the immune system’s CD4 T-cells. But researchers have only observed the virus killing a small portion of those cells, leading to a longstanding question: What makes the other cells disappear? New research shows that the body is killing its own cells in a little-known process. What’s more, an existing, safe drug could interrupt that self-destruction, thereby offering a way to treat AIDS.
Warner Greene from the Gladstone Institute of Virology and Immunology has been trying to solve the mystery of HIV inffection for years, and he thinks he has finally cracked it. In two papers, published simultaneously in Science and Nature, his team lays out why HIV kills so many bystander cells and, better still, a possible way of stopping it.
Scientists say they have discovered a key process by which the AIDS virus kills key immune cells: It triggers a preprogrammed self-destruct sequence within the cell that is intended to alert fellow immune cells of a crisis.
An anti-inflammatory drug shelved by Vertex Pharmaceuticals Inc. after a mid-stage study in epilepsy patients could be the next big HIV treatment.
Scientists have discovered that the AIDS virus destroys the immune system by infecting a relatively few number of cells that create a fiery pathway that consumes nearby cells. Finding could lead to treatments to dampen disease activity.
U.S. scientists have discovered the basic mechanisms that allow HIV to wipe out the body's immune system and cause AIDS, which could lead to new approaches to treatment and research for a cure for the disease that affects 35 million people around the world.
Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.
The reason people who are infected with HIV die is because their white blood cells die, leaving them unable to fight infections. Now, researchers show for the first time that this cell death is caused by cellular self-destruction, and is linked with inflammation.
In uncontrolled HIV infection, an over-the-top immune response causes much of the damage that leads to AIDS, researchers are reporting.
HIV infection causes a mass suicide of immune cells — a process that can be halted by an experimental drug that blocks cellular self-destruction, studies in cell cultures suggest. Researchers are now proposing a clinical trial of the drug in people with HIV.