Gladstone in the News

The Gladstone Institutes is gratified to receive media attention from around the globe. Check out the highlights of recent press coverage of Gladstone scientists and research. For other news, please be sure to follow us on Facebook and Twitter.

Drug blocks HIV in lab study, human tests planned
December 19, 2013

Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.

HIV's Killer Tactics Revealed, New Therapy Approach Found
December 19, 2013

The reason people who are infected with HIV die is because their white blood cells die, leaving them unable to fight infections. Now, researchers show for the first time that this cell death is caused by cellular self-destruction, and is linked with inflammation.

HIV Mechanism: 'Suicide, not Murder'
December 19, 2013

In uncontrolled HIV infection, an over-the-top immune response causes much of the damage that leads to AIDS, researchers are reporting.

Cell-suicide blocker holds promise as HIV therapy
December 19, 2013

HIV infection causes a mass suicide of immune cells — a process that can be halted by an experimental drug that blocks cellular self-destruction, studies in cell cultures suggest. Researchers are now proposing a clinical trial of the drug in people with HIV.

How HIV Destroys Immune Cells
December 19, 2013

HIV leads to AIDS primarily because the virus destroys essential immune cells called CD4 T cells, but precisely how these cells are killed has not been clear. Two papers published simultaneously today (19 December) in Nature and Science reveal the molecular mechanisms that cause the death of most CD4 T cells in lymphoid tissues, the main reservoir for such cells, during infection.

AIDS Mystery Solved: 2 US Studies Show How HIV Progresses To Final Stage
December 19, 2013

A set of breakthrough studies from U.S. scientists reveals for the first time the fundamental biological mechanism whereby HIV unravels the body’s defenses and causes AIDS, setting the stage for a new generation of sophisticated interventions and preventative treatments.

New studies detail how HIV affects immune system, claim drug exists to block virus
December 19, 2013

In a last-ditch effort to rid the body of HIV, droves of white bloods cells self-destruct in an explosive mass suicide that drives the progression toward AIDS, a pair of new studies has found.

Cells' Fiery Suicide in HIV Provides New Treatment Hope
December 19, 2013

The difference between HIV infection and full-blown AIDS is, in large part, the massive die-off of the immune system’s CD4 T-cells. But researchers have only observed the virus killing a small portion of those cells, leading to a longstanding question: What makes the other cells disappear? New research shows that the body is killing its own cells in a little-known process. What’s more, an existing, safe drug could interrupt that self-destruction, thereby offering a way to treat AIDS.

The Noisy Mass Suicide That Leads to AIDS
December 19, 2013

Warner Greene from the Gladstone Institute of Virology and Immunology has been trying to solve the mystery of HIV inffection for years, and he thinks he has finally cracked it. In two papers, published simultaneously in Science and Nature, his team lays out why HIV kills so many bystander cells and, better still, a possible way of stopping it.

HIV infection causes immune cells to self-destruct, study says
December 19, 2013

Scientists say they have discovered a key process by which the AIDS virus kills key immune cells: It triggers a preprogrammed self-destruct sequence within the cell that is intended to alert fellow immune cells of a crisis.